And So the Seasons Go!

So where do we go from here?

i First, I would like to thank Bernd Carsten Stahl for the opportunity to write this editorial, and for his vision, hard work, and dedication. It also has been a privilege to work with the editorial team, the reviewers, and, of course, the authors. IJTHI is off to a good start. It has been exciting for me to be part of a new journal and to see it go from just a concept to its fourth issue. Alth...

So We Don't Go for ‘the Big (type) “o”’ – so What?

HIF-1 regulation: not so easy come, easy go.

The hypoxia-inducible factor-1 (HIF-1) is the master regulator of the cellular response to hypoxia and its expression levels are tightly controlled through synthesis and degradation. It is widely accepted that HIF-1alpha protein accumulation during hypoxia results from inhibition of its oxygen-dependent degradation by the von Hippel Lindau protein (pVHL) pathway. However, recent data describe n...

So you want to go to graduate school.

“So go down town”: simulating pedestrian movement in town centres

Pedestrian movement models have been developed since the 1970s. A review of the literature shows that such models have been developed to explain and predict macro, meso and micro movement patterns. However, recent developments in modelling techniques, and especially advances in agent-based simulation, open up the possibility of developing integrative and complex models which use existing models...